| 2026-09-04 |
Fermat's Last Theorem formalized end to end in Lean 4 |
Anthropic |
Internal Anthropic research model, described in the announcement as roughly comparable to Claude Fable 5.1 |
Formally verified |
AI-led |
mathematics |
| 2026-09-03 |
Lean disproof of Krempa's matrix form of the Koethe conjecture |
OpenAI / Epoch AI |
GPT-6 Astra (pre-release) |
Formally verified |
Autonomous |
mathematics |
| 2026-09-03 |
Erdos-Sos conjecture proved in Lean, in a form marginally weaker than the classical statement |
OpenAI / Epoch AI |
GPT-6 Astra (pre-release) |
Formally verified |
Autonomous |
mathematics |
| 2026-09-03 |
Disputed claim that Catalan's constant is irrational |
Nanjing University |
ChatGPT 5.6 Solar, named in the paper as the verifier; the model consulted during the work is named only as AI |
Disputed |
AI-assisted |
mathematics |
| 2026-09-02 |
A quantum oracle separating QMA(2) from QMA |
MIT / Columbia / University of Washington |
ChatGPT 5.6 Sol |
Author verified |
AI-assisted |
computer-science |
| 2026-09-02 |
Confirmation of the Daykin-Frankl conjecture from a language-model proof |
Independent |
GPT-5.6 Sol Pro |
Author verified |
AI-led |
mathematics |
| 2026-09-02 |
A smooth counterexample to the Trautman conjecture |
Oklahoma State University |
ChatGPT Plus, version not named |
Author verified |
AI-assisted |
mathematics |
| 2026-09-01 |
Entropy production of the Boltzmann equation is not always monotone |
Independent |
GPT-5.6 Sol; Claude |
Author verified |
AI-led |
mathematics |
| 2026-09-01 |
Common neighbour conjectures for Saxl graphs fail at every base size |
Independent |
Codex; ChatGPT Pro; Claude |
Formally verified |
Collaborative |
mathematics |
| 2026-08-31 |
Counterexample to the stable forking conjecture |
Independent |
GPT-5.6 Sol |
Author verified |
Collaborative |
mathematics |
| 2026-08-31 |
Unrestricted Boolean multiplicative complexity of four-term binary polynomial multiplication |
Independent |
GPT-5.6 Sol; Claude Opus 5 |
Formally verified |
AI-assisted |
computer-science |
| 2026-08-31 |
Criteria and two quadratic instances for Bugeaud's Problem 10.61 |
Independent |
Claude Fable 5; Claude Opus 5 |
Claimed |
AI-led |
mathematics |
| 2026-08-29 |
Dean's conjecture for k = 5, cycles of length divisible by five |
Independent |
GPT-5.6 Sol; Claude Opus 5; GLM 5.3 Flash |
Claimed |
AI-led |
mathematics |
| 2026-08-29 |
Randomized metric distortion improved to 2.3282 |
Independent |
GPT-5.6 Sol; Claude Opus 5.0 |
Author verified |
AI-led |
computer-science |
| 2026-08-28 |
Lean proof that the percolation probability vanishes at the critical point in every dimension |
Anthropic |
Anthropic Claude models, versions not stated |
Claimed |
AI-led |
mathematics |
| 2026-08-27 |
Hyperbolic surfaces with large systoles in every large genus |
Independent |
GPT-5.6 Sol |
Author verified |
AI-led |
mathematics |
| 2026-08-27 |
Not every Heyting algebra is the subterminal lattice of a topos |
Independent |
ChatGPT 5.6 Sol |
Author verified |
AI-assisted |
mathematics |
| 2026-08-27 |
Supporting affine functionals for entanglement of formation need not exist |
Independent |
Claude Fable 5 |
Author verified |
AI-assisted |
physics |
| 2026-08-26 |
Counterexample to Nevanlinna's half-plane omitted-values question |
Independent |
GPT-5.6 Sol Ultra |
Author verified |
AI-led |
mathematics |
| 2026-08-26 |
Rapid mixing for spin systems on graphs of girth at least five |
Independent |
GPT-5.6 Sol Ultra |
Author verified |
Collaborative |
computer-science |
| 2026-08-25 |
Improved algebraic construction for off-diagonal Ramsey numbers |
Independent |
ChatGPT 5.6 |
Author verified |
AI-assisted |
mathematics |
| 2026-08-25 |
Improved lower bound for large gaps between consecutive primes |
Independent |
GPT-5.6 Sol |
Independently checked |
AI-led |
mathematics |
| 2026-08-25 |
Sparse domination implies convex body domination |
Independent |
GPT-5.6 Sol Pro |
Author verified |
AI-assisted |
mathematics |
| 2026-08-25 |
Equivalence of generic stability notions for Keisler measures |
Independent |
ChatGPT 5.5; ChatGPT 5.6 Sol; Kimi K3; Claude Fable 5 |
Author verified |
AI-led |
mathematics |
| 2026-08-25 |
Fröberg's conjecture for quintics and septics in four variables |
Independent |
GPT-5.6 Sol; Claude Fable 5; Grok 4.6 |
Author verified |
Collaborative |
mathematics |
| 2026-08-24 |
Optimal linear encoding rate for lossy compression of Bernoulli sources |
Independent |
GPT-5.6 Sol |
Author verified |
AI-led |
computer-science |
| 2026-08-23 |
A proposed complex structure on the six-sphere |
Anthropic |
Claude, version not stated |
Claimed |
AI-assisted |
mathematics |
| 2026-08-23 |
Elliptic curves over the rationals of rank at least 30 and at least 31 |
Independent |
Claude |
Claimed |
AI-assisted |
mathematics |
| 2026-08-22 |
Transcendence in the affine case of Erdős Problem 270 |
Independent |
GPT-5.6 Sol (Codex) |
Claimed |
AI-led |
mathematics |
| 2026-08-21 |
Dubickas's question on integral parts of powers of square roots settled |
Independent |
Claude Fable 5 and Claude Opus 5 |
Formally verified |
AI-led |
mathematics |
| 2026-08-21 |
Stable commutator length of a relator is not a one-relator group invariant |
Independent |
Claude Opus 5; Harmonic Aristotle |
Author verified |
AI-assisted |
mathematics |
| 2026-08-21 |
Counterexample to the bounded mass property on the Hopf threefold |
Independent |
Rethlas agent (GPT-5.6 Sol) |
Author verified |
AI-led |
mathematics |
| 2026-08-20 |
Marton's inner bound shown not to reach the broadcast channel capacity region |
Independent |
GPT-5.6 Sol, Claude Fable 5 and Claude Opus 5 |
Author verified |
AI-assisted |
computer-science |
| 2026-08-20 |
A smooth random fast dynamo on the three-torus |
Independent |
ChatGPT 5.6 Sol Ultra |
Author verified |
AI-led |
mathematics |
| 2026-08-20 |
Counterexamples to the fractional colouring conjecture for Pauli shadow tomography |
Independent |
GPT-5.6 Sol |
Author verified |
Collaborative |
physics |
| 2026-08-19 |
Counterexample to the Yau–Tian–Donaldson conjecture for constant scalar curvature metrics |
Independent |
Claude Fable 5, GPT-5.6-sol and Danus |
Author verified |
Collaborative |
mathematics |
| 2026-08-19 |
Counterexample to the smooth Carathéodory conjecture on umbilic points |
Independent |
Claude; Codex |
Claimed |
AI-assisted |
mathematics |
| 2026-08-19 |
First open case of the big-line-big-clique conjecture |
Independent |
GPT-5.6 Sol Pro |
Author verified |
AI-led |
mathematics |
| 2026-08-19 |
Counting linear extensions below the 2^n barrier |
Independent |
Claude Opus 5; ChatGPT 5.6 Sol |
Author verified |
AI-led |
computer-science |
| 2026-08-19 |
Erdős Problem #501 shown independent of ZFC, with both directions in Lean |
Independent |
Sol; Claude |
Formally verified |
Collaborative |
mathematics |
| 2026-08-19 |
The DeLaViña-Waller conjecture on the Wiener index |
Independent |
GPT-5.6 Sol; Claude Fable 5 |
Author verified |
AI-assisted |
mathematics |
| 2026-08-19 |
Partial proof of the Kasami APN triple-count conjecture, verified in Lean |
Independent |
Claude Fable 5; Harmonic Aristotle |
Formally verified |
AI-led |
mathematics |
| 2026-08-18 |
Bounded prime gaps of 246 formalized in Lean from Bombieri-Vinogradov |
Axiom Math |
AxiomProver |
Formally verified |
Collaborative |
mathematics |
| 2026-08-18 |
Dimension-free weak-type bound for the vector Riesz transform |
Independent |
GPT-5.6 Sol and Claude Opus 5.0, with Danus and Rethlas agents |
Author verified |
Collaborative |
mathematics |
| 2026-08-17 |
Matrix multiplication exponent lowered to below 2.371177 |
Google DeepMind |
AlphaEvolve |
Author verified |
Search scaffold |
computer-science |
| 2026-08-16 |
Talagrand's convolution conjecture proved on the Boolean hypercube |
Independent |
Odin Automatic AI Research Agent |
Author verified |
AI-led |
mathematics |
| 2026-08-13 |
SOP_2 and SOP_3 theories shown to coincide |
Independent |
ChatGPT 5.6 |
Author verified |
Collaborative |
mathematics |
| 2026-08-13 |
Banach's isometric conjecture settled in the remaining odd dimensions |
Independent |
ChatGPT 5.5 Pro, ChatGPT 5.6 Pro and GPT-5.6 Sol |
Author verified |
AI-assisted |
mathematics |
| 2026-08-12 |
Complete minimizer picture for Gamow's liquid drop model |
Independent |
ChatGPT 5.6 Pro |
Author verified |
AI-led |
mathematics |
| 2026-08-11 |
A prescribed Hamiltonian cycle that a book-embedding algorithm cannot produce |
Independent |
OpenAI Codex, with Claude for adversarial review |
Formally verified |
AI-assisted |
computer-science |
| 2026-08-10 |
Proportion of zeta zeros on the critical line raised to 67.25% |
Anthropic |
Claude (unreleased research version) |
Formally verified |
AI-led |
mathematics |
| 2026-08-08 |
A 112-vertex counterexample to the Petersen coloring conjecture |
Independent |
Unnamed OpenAI model |
Formally verified |
AI-assisted |
mathematics |
| 2026-08-06 |
Separation between the ordinary and strong Kreiss constants |
Independent |
ChatGPT 5.6 Pro; Claude Fable |
Author verified |
AI-assisted |
mathematics |
| 2026-08-05 |
Sendov's conjecture proved for every degree |
Independent |
GPT-5.6 Pro |
Formally verified |
Collaborative |
mathematics |
| 2026-08-05 |
Counterexamples to Schiffer's conjecture and the Pompeiu problem |
Independent |
GPT-5.6, Claude Opus 4.8, Claude Fable 5 |
Formally verified |
AI-assisted |
mathematics |
| 2026-08-04 |
Asymptotic degree-diameter problem resolved for fixed diameter |
Independent |
GPT-5.6 Pro |
Formally verified |
AI-assisted |
mathematics |
| 2026-08-01 |
Ten results in mathematics and theoretical computer science with Lean certificates |
OpenAI |
Astra |
Formally verified |
AI-led |
mathematics |
| 2026-07-29 |
Optimal exponent relating sumsets and difference sets determined |
Tencent Hunyuan |
Hy3 (Hyra research agent) |
Formally verified |
AI-led |
mathematics |
| 2026-07-28 |
Kemeny rank aggregation shown NP-hard for three voters |
Independent |
GPT-5.6 Sol Ultra, Claude Fable 5 |
Formally verified |
AI-led |
computer-science |
| 2026-07-27 |
Feige's conjecture on sums of nonnegative random variables settled |
Independent |
ChatGPT 5.6 Pro |
Formally verified |
AI-led |
mathematics |
| 2026-07-22 |
Counterexample to the Dinitz–Garg–Goemans conjecture |
Independent |
GPT-5.6 Pro |
Claimed |
AI-led |
computer-science |
| 2026-07-20 |
Counterexamples to the Gaussian moments conjecture |
Independent |
GPT-5.6 Sol Pro + Claude Fable 5 |
Author verified |
AI-led |
mathematics |
| 2026-07-20 |
Eight problems from the Kourovka Notebook solved and formalized in Lean |
Harmonic |
Aristotle |
Formally verified |
Autonomous |
mathematics |
| 2026-07-20 |
Gaussian product inequality conjecture proved |
Independent |
ChatGPT 5.6 Sol |
Formally verified |
AI-led |
mathematics |
| 2026-07-19 |
Counterexample to the Jacobian conjecture in dimension three |
Anthropic |
Claude Fable 5 |
Formally verified |
Collaborative |
mathematics |
| 2026-07-14 |
Near-quadratic lower bound for derivative-free convex optimization |
Independent |
GPT-5.6 Sol Pro |
Formally verified |
AI-led |
mathematics |
| 2026-07-14 |
Sabidussi's compatibility conjecture proved |
Independent |
GPT-5.6 Pro, GPT-5.6 Sol |
Formally verified |
Collaborative |
mathematics |
| 2026-07-11 |
Counterexample to Grothendieck's question on finite flat group schemes |
Independent |
OpenAI Sol (construction); Claude Fable (Lean formalisation) |
Formally verified |
Collaborative |
mathematics |
| 2026-07-10 |
Cycle double cover conjecture proved for all bridgeless multigraphs |
OpenAI |
GPT-5.6 Sol Ultra |
Formally verified |
AI-led |
mathematics |
| 2026-06-25 |
First Herculaneum scroll read end to end without unrolling it |
Vesuvius Challenge |
Community-developed ink-detection neural networks |
Author verified |
AI-assisted |
archaeology |
| 2026-06-17 |
Two kagome superconductors predicted by machine learning and confirmed in the lab |
Aalto University / Rice University |
Unknown |
Peer reviewed |
Search scaffold |
materials |
| 2026-06-02 |
Identity for the critical exponents of jamming derived analytically |
Independent |
Claude Sonnet 4.6, Claude Opus 4.7 |
Peer reviewed |
Collaborative |
physics |
| 2026-05-21 |
Nine Erdős problems and 44 OEIS conjectures proved with machine-checked proofs |
Google DeepMind |
AlphaProof Nexus (LLM + Lean) |
Formally verified |
Search scaffold |
mathematics |
| 2026-05-20 |
Disproof of the Erdős unit-distance conjecture |
OpenAI |
GPT-5 series reasoning model |
Independently checked |
AI-led |
mathematics |
| 2026-05-18 |
Phase 1 trial of a computationally designed pan-sarbecovirus vaccine |
University of Cambridge / DIOSynVax |
Unknown |
Peer reviewed |
AI-assisted |
medicine |
| 2026-04-23 |
An antibiotic designed by reinforcement learning clears an MRSA infection in mice |
McMaster University / Stanford University |
SyntheMol-RL |
Peer reviewed |
Search scaffold |
medicine |
| 2026-01-15 |
Structure in Bruhat intervals of permutation groups |
Google DeepMind |
AlphaEvolve (Gemini-based) |
Independently checked |
Search scaffold |
mathematics |
| 2026-01-13 |
Erdős problem #728 resolved and formalized in Lean |
OpenAI / Harmonic |
GPT-5.2 Pro + Aristotle |
Formally verified |
Autonomous |
mathematics |
| 2025-11-20 |
Early science acceleration experiments with GPT-5 |
OpenAI |
GPT-5 |
Peer reviewed |
AI-assisted |
computer-science |
| 2025-11-03 |
AlphaEvolve across 67 problems: 20 improvements, 8 regressions |
Google DeepMind |
AlphaEvolve (Gemini-based) |
Independently checked |
Search scaffold |
mathematics |
| 2025-10-19 |
GPT-5 "solved 10 Erdős problems": it located existing solutions |
OpenAI |
GPT-5 |
Already known |
Retrieval |
mathematics |
| 2025-09-25 |
Limits to black-box amplification in QMA, with the key step written by GPT-5 |
UT Austin / CWI Amsterdam |
GPT-5 Thinking |
Author verified |
AI-assisted |
computer-science |
| 2025-09-17 |
New families of unstable singularities in fluid equations |
Google DeepMind (with Brown, NYU and Stanford) |
Physics-informed neural networks with Gauss–Newton optimisation |
Author verified |
Search scaffold |
mathematics |
| 2025-09-17 |
AI-generated bacteriophage genomes that replicate and kill bacteria |
Arc Institute / Stanford University |
Evo 1 and Evo 2 |
Peer reviewed |
AI-led |
biology |
| 2025-09-11 |
Strong prime number theorem formalized in Lean by an autoformalization agent |
Math, Inc. |
Gauss (autoformalization agent) |
Author verified |
AI-assisted |
mathematics |
| 2025-08-01 |
Improved step-size bound in smooth convex optimization |
OpenAI |
GPT-5 Pro |
Already known |
AI-assisted |
mathematics |
| 2025-07-28 |
Machine-checked Lean proofs for five of six 2025 IMO problems |
Harmonic |
Aristotle |
Formally verified |
AI-led |
mathematics |
| 2025-07-21 |
Gold-medal standard at the 2025 International Mathematical Olympiad |
Google DeepMind |
Gemini Deep Think (advanced version) |
Independently checked |
AI-led |
mathematics |
| 2025-06-03 |
Phase 2a results for a drug whose target and molecule both came from AI |
Insilico Medicine |
PandaOmics (target) + Chemistry42 (molecule) |
Peer reviewed |
Search scaffold |
medicine |
| 2025-05-14 |
4×4 complex matrix multiplication in 48 scalar multiplications |
Google DeepMind |
AlphaEvolve (Gemini-based) |
Independently checked |
Search scaffold |
computer-science |
| 2025-05-14 |
Improved lower bound for the 11-dimensional kissing number |
Google DeepMind |
AlphaEvolve (Gemini-based) |
Independently checked |
Search scaffold |
mathematics |
| 2025-05-14 |
Improved bound for the Erdős minimum-overlap problem |
Google DeepMind |
AlphaEvolve (Gemini-based) |
Independently checked |
Search scaffold |
mathematics |
| 2025-05-01 |
Candidate treatment for dry age-related macular degeneration |
FutureHouse |
Robin (multi-agent) |
Peer reviewed |
AI-led |
biology |
| 2025-03-12 |
A fully machine-generated paper passed workshop peer review |
Sakana AI |
The AI Scientist-v2 |
Author verified |
AI-led |
computer-science |
| 2025-02-19 |
AI co-scientist hypotheses on antimicrobial resistance and liver fibrosis |
Google |
AI Co-Scientist (Gemini 2.0 multi-agent) |
Peer reviewed |
AI-assisted |
biology |
| 2025-02-13 |
Enzymes with working catalytic machinery designed from scratch |
Institute for Protein Design, University of Washington |
RFdiffusion with PLACER ensemble scoring |
Peer reviewed |
Search scaffold |
chemistry |
| 2025-01-16 |
A working fluorescent protein generated by a language model |
EvolutionaryScale |
ESM3 (98B) |
Peer reviewed |
AI-led |
biology |
| 2025-01-16 |
Generative model designs crystals to order; its flagship synthesis turned out to be a known compound |
Microsoft Research |
MatterGen |
Disputed |
Search scaffold |
materials |
| 2024-11-20 |
A neural decoder that identifies quantum errors more accurately than hand-designed methods |
Google DeepMind / Google Quantum AI |
AlphaQubit |
Peer reviewed |
AI-led |
physics |
| 2024-10-02 |
Complete wiring diagram of an adult fruit-fly brain |
FlyWire Consortium (Princeton, MRC LMB, Cambridge, Vermont) |
Automated electron-microscopy segmentation networks |
Peer reviewed |
AI-assisted |
neuroscience |
| 2024-07-25 |
Silver-medal standard at the 2024 International Mathematical Olympiad |
Google DeepMind |
AlphaProof + AlphaGeometry 2 |
Independently checked |
AI-led |
mathematics |
| 2024-05-08 |
Joint structure prediction for proteins, nucleic acids and ligands (AlphaFold 3) |
Google DeepMind / Isomorphic Labs |
AlphaFold 3 |
Peer reviewed |
AI-led |
biology |
| 2024-02-21 |
Reinforcement learning steers a tokamak away from tearing instabilities |
Princeton University / PPPL / DIII-D National Fusion Facility |
Deep reinforcement learning controller over a learned plasma model |
Peer reviewed |
Search scaffold |
physics |
| 2024-01-17 |
Olympiad geometry solved without human demonstrations |
Google DeepMind |
AlphaGeometry |
Peer reviewed |
Search scaffold |
mathematics |
| 2023-12-20 |
A language-model agent that planned and ran chemistry experiments on lab robots |
Carnegie Mellon University |
GPT-4 (Coscientist agent) |
Peer reviewed |
AI-led |
chemistry |
| 2023-12-20 |
A new structural class of antibiotic candidates against MRSA |
MIT / Broad Institute / Harvard |
Ensembles of graph neural networks with substructure attribution |
Peer reviewed |
Search scaffold |
chemistry |
| 2023-12-14 |
New lower bound constructions for the cap set problem |
Google DeepMind |
FunSearch (PaLM 2 / Codey) |
Peer reviewed |
Search scaffold |
mathematics |
| 2023-12-14 |
Improved heuristics for online bin packing |
Google DeepMind |
FunSearch (PaLM 2 / Codey) |
Peer reviewed |
Search scaffold |
computer-science |
| 2023-11-29 |
Large-scale prediction of new stable crystalline materials (GNoME) |
Google DeepMind |
GNoME (graph neural network) |
Disputed |
Search scaffold |
materials |
| 2023-11-29 |
Autonomous laboratory reports solid-state synthesis of new inorganic compounds |
Lawrence Berkeley National Laboratory |
A-Lab (ML planning + robotics) |
Disputed |
AI-led |
materials |
| 2023-11-14 |
Medium-range weather forecasts from a graph neural network beat the operational physics model |
Google DeepMind |
GraphCast |
Peer reviewed |
AI-led |
climate |
| 2023-09-19 |
Pathogenicity predictions for 71 million human missense variants |
Google DeepMind |
AlphaMissense |
Peer reviewed |
AI-led |
medicine |
| 2023-06-07 |
Faster sorting routines discovered and merged into the LLVM C++ library |
Google DeepMind |
AlphaDev (AlphaZero-based) |
Independently checked |
Search scaffold |
computer-science |
| 2022-10-05 |
Faster matrix-multiplication algorithms found by reinforcement learning |
Google DeepMind |
AlphaTensor (AlphaZero-based) |
Peer reviewed |
Search scaffold |
computer-science |
| 2022-02-16 |
Deep reinforcement learning controls tokamak fusion plasma |
Google DeepMind |
DeepMind RL controller |
Peer reviewed |
Search scaffold |
physics |
| 2021-12-01 |
Two theorems found by machine pattern-spotting in knot theory and representation theory |
Google DeepMind (with Oxford and Sydney) |
Supervised networks with gradient-based attribution |
Peer reviewed |
AI-assisted |
mathematics |
| 2021-07-15 |
Accurate protein structure prediction across the known proteome (AlphaFold2) |
Google DeepMind |
AlphaFold2 |
Independently checked |
AI-led |
biology |
| 2021-04-29 |
Reinforcement learning refutes several conjectures in extremal combinatorics |
Tel Aviv University |
Deep cross-entropy method (custom network) |
Independently checked |
Search scaffold |
mathematics |
| 2020-02-20 |
Halicin, an antibiotic found by a neural network screening a compound library |
MIT / Broad Institute |
Directed message-passing graph neural network (Chemprop) |
Peer reviewed |
Search scaffold |
medicine |
| 2017-12-14 |
An eighth planet around Kepler-90 found by a neural network |
Google Brain / University of Texas at Austin |
Convolutional neural network (AstroNet) |
Peer reviewed |
Search scaffold |
astronomy |